Guy E . Meadows , Helen M . A . Dunroy , Mary J . Morrell and Douglas R . Corfield humans , during sleep compared with wakefulness
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humans, during sleep compared with wakefulness Hypercapnic cerebral vascular reactivity is decreased, in You might find this additional info useful... physiology, especially those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a publishes original papers that deal with diverse area of research in applied
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Hypercapnic cerebral vascular reactivity is decreased, in humans, during sleep compared with wakefulness.
During wakefulness, increases in the partial pressure of arterial CO(2) result in marked rises in cortical blood flow. However, during stage III-IV, non-rapid eye movement (NREM) sleep, and despite a relative state of hypercapnia, cortical blood flow is reduced compared with wakefulness. In the present study, we tested the hypothesis that, in normal subjects, hypercapnic cerebral vascular react...
متن کاملCerebral blood flow response to isocapnic hypoxia during slow-wave sleep and wakefulness.
Nocturnal hypoxia is a major pathological factor associated with cardiorespiratory disease. During wakefulness, a decrease in arterial O2 tension results in a decrease in cerebral vascular tone and a consequent increase in cerebral blood flow; however, the cerebral vascular response to hypoxia during sleep is unknown. In the present study, we determined the cerebral vascular reactivity to isoca...
متن کاملCardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans.
The cardiovascular response to an arousal occurring at the termination of an obstructive apnea is almost double that to a spontaneous arousal. We investigated the hypothesis that central plus peripheral chemoreceptor stimulation, induced by hypercapnic hypoxia (HH), augments the cardiovascular response to arousal from sleep. Auditory-induced arousals during normoxia and HH (>10-s duration) were...
متن کاملOvernight changes in the cerebral vascular response to isocapnic hypoxia and hypercapnia in healthy humans: protection against stroke.
BACKGROUND AND PURPOSE The reduction in hypercapnic cerebral vascular reactivity that occurs in the morning after sleep is associated with an increased risk of cerebral ischemia and stroke. It is not known if the cerebral vascular response to hypoxia is similarly reduced in the morning, but such a reduction could be considered a further risk factor for cerebral vascular disease. METHODS To te...
متن کاملHippocampal Hypertrophy and Sleep Apnea: A Role for the Ischemic Preconditioning?
The full impact of multisystem disease such as obstructive sleep apnoea (OSA) on regions of the central nervous system is debated, as the subsequent neurocognitive sequelae are unclear. Several preclinical studies suggest that its purported major culprits, intermittent hypoxia and sleep fragmentation, can differentially affect adult hippocampal neurogenesis. Although the prospective biphasic na...
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